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Antioxidant therapy in cases of aspirin, prescribed with antiplatelet aim

Thrombosis is recognized as the main complication of coronary heart disease. It is considered as the main cause of death in patients with diabetes mellitus (type I and II). With a view to preventing it, all “diabetics” need antiplatelet therapy, and Aspirin is the drug of choice.

However, in some cases, diabetes mellitus can cause such clotting disorders, in which a thrombogenic predisposition develops. In this situation, standard therapy with Aspirin is ineffective. Acetylsalicylic acid, inactivating type 1, cyclooxygenase, inhibition and treats atherothrombotic disorders in most cases. A2, which manifests thrombogenic properties. But this does not always happen. Some serious cardiovascular complications in patients with diabetes mellitus have a high risk of being associated with Aspirin’s “failure” to block of cyclooxygenase type 1. This is the basis for the study.

As a result, it has been shown that preparations with antioxidant action and dietary nutrition, based on the sufficient use of foods, are rich in antioxidants, can prevent this failure. Such properties have ascorbic acid, tocopherol and polyphenols. Therefore, patients with diabetes should take not only Aspirin, but also complex multivitamin complexes, and also to revise the diet of their own food. Antioxidant therapy in combination with acetylsalicylic acid is a proven and effective way of preventing and possibly treating atherothrombotic complications.

To reveal the predisposition of the organism in increased incomes of antioxidants, if a person suffers from diabetes, it is quite simple – it is necessary to conduct a coagulogram. The state of hypercoagulability against the background of taking Aspirin indicates its “failure” to work (aspirin resistance). Such patients need ascorbic acid, tocopherol and polyphenols. Further studies are needed to determine the most effective dose of these substances.

Antenatalally administered corticosteroids and their effect on daily cortisol management in children

Rapid rates of fetal development in the embryonic period, which are influenced from outside, can affect the further development of the central nervous system. This can lead to a change in mental and physical health. One of the external influences are the glucocorticoids given to the mother during pregnancy in order to prevent premature birth. They are able to re-program the child’s further development. However, it is not yet known in which direction the reprogramming will take place.

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A common corticosteroid used in obstetrical practice is Betamethasone. It is prescribed to prevent premature termination of pregnancy. In 25% of cases, children, whose mothers took Betamethasone, are born on time. They were the subject of research.

Several studies have examined the antenatal effect of Betamethasone on the circadian rhythm of the hypothalamic-pituitary-adrenal system of children born. The purpose of this study was to determine whether there is a connection between these factors and how strong it is for children born on time.

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Pharmaceutical professionals are working to improve the safety of taking medications

Medicines were created, first of all, for human treatment. However, every year the cause of poisoning and death of more than 500 thousand people in the world are just medicines.

The first problem is incorrectly prescribed, including by specialists, medicines. In order to help doctors better navigate among a large number of drugs and avoid mistakes in the appointment, experienced doctors, researchers and scientists. Their study helps to avoid mistakes and stay abreast of the latest developments. One such runet project is the electronic medicinal guide GEOTAR . All materials presented on the site are prepared by experts in the field of pharmaceutics.

Another reason why drugs are becoming a threat to life is counterfeit pharmaceutical products. American universities – Heimlana and Notre Dame. They developed an easy-to-use test that could identify fake and expired antibiotics.

Mostly from counterfeit drugs people from the third world countries and developing countries suffer, where most fakes come. However, the problem of substandard and counterfeit medicines is often encountered in developed countries, where counterfeit drugs are used to treat drugs hit the counter

Another factor that influences the quality of drugs is the climate. When delivered to countries with hot climates and high temperatures, some medicines lose their medicinal properties and even become life-threatening.

To help people avoid using counterfeit and expired medications, scientists Sarah Bliz and Marya Lieberman created a unique test that helps determine the quality of the most sought-after antibiotics.

The test is a card on which there are 12 strips with various reagents. To check the medicine, you need to pour on the card powdered pill so that the drug is on all 12 strips. Then the tips of the strips are immersed in water for 3 minutes. In contact with the substances contained in the drug, the reagents are colored. The results are compared with the standard attached to the test. Also for comparison, you can use a special application.

The developers of the test took care not only of the ease of use of the test, but also of its availability: the estimated price at which the invention will be sold is only 1 dollar. Scientists hope that due to low cost and simplicity the test will receive a mass application and will help reduce the number of poisonings with expired and counterfeit medicines.

Prevalence, clinical characteristics and precursors in patients with Takotsubo cardiomyopathy complicated by thromboembolism

Several acute complications associated with Tacotubo’s cardiomyopathy (TTC) have been described in the scientific literature lately. No, the incidence and clinical significance of the acute thromboembolic processes in TTS has not yet been established.

A study of scientists from Heidelberg University, Mannheim, Germany, diagnosed patients with TTC between January 2003 and September 2015. This study was initiated to identify predictors, clinical significance, and short-term and long- term treatment in patients with TTS associated with acute thromboembolism.

As a result, it was found that the incidence of acute thromboembolic complications with TTC was about 12.2%. They included ventricular thrombi, cerebrovascular events, pathology of retinal arteries, brachial, renal, splenic arteries and aorta. The most frequent complication in the initial stage of the disease was cardiogenic shock (20%), which was accompanied by the development of pulmonary edema (20%). It is important to note that patients with thromboembolism had higher levels of C-reactive protein (CRP) compared to the non-erboembolic group of patients (P = 0.02). Certain thromboembolic states were characterized by the presence of ST-segment elevation in the electrocardiogram (P = 0.02). Chest pain was the main symptom in this category of patients (p = 0.09).Besides, significant involvement of the right ventricle in the pathological process was noted (according to the estimation of transthoracic echocardiography, P = 0.08). The Kaplan-Meier analysis showed a significantly higher mortality rate during the mean-follow-up period of three years in the thromboembolism group (P = 0.02).

Thus, the results of the study confirmed the relative total risk of thromboembolic events with TTS. Inflammation can also play an important role in the development of thromboembolic complications. Involving the right ventricle process, raising the ST-segment ECG can be positive predictive criteria in such cases. In order to reduce the risk of anemic outcome, it is recommended to begin anticoagulant therapy in all patients at high risk.

Existing methods of lengthening the penis in the treatment of Peyronie’s disease. Overview

Shortening of the penis is one of the most common complaints of men with Peyronie’s disease (BP), both before and after surgery. This has a significant negative impact on the patient’s quality of life.

Based on the Columbia University Medical Center, the Department of Urology, a systematic review of the methods by which the length of the penis can be preserved or enlarged. The review was based on the search in the PUBMED database of articles published between 1990 and 2015. The articles with the key words “Peyronie’s disease”, “penis length” and / or “lengthening of the penis” about subjective or objective results of penile length changes. The review included only English-language articles that concerned BP and the size of the penis.

The researchers did not find any evidence in the literature about the advantageous effectiveness of the technique in the shortening of the penis in front of the other. The classic operation of installing an inflatable prosthesis of the penis, the procedure of plication and the procedure of Nesbit. Excision of plaques and transplantation can increase the length of the penis, but can not be complicated in the postoperative period by erectile dysfunction. There are several surgical procedures that are based on the use of an inflatable prosthesis in men with concomitant erectile dysfunction, while maintaining the length of the penis and improving sexual function.These include the subcoronal prosthetics of the penis, the peripheral technique of Egidio (Egydio), the sliding and modified sliding techniques and the technique of “multiple slices”. In addition, such adjuvant therapies as penile stretching therapy, postoperative penile inflation protocols, suspension techniques for ligament relaxation, lipectomy and surgical methods for treating penile engorgement aimed at subjective or objective penis enlargement in men are associated with a high risk of depression length in the postoperative period. Therefore, they can not be recommended as a routine.Lipectomy and surgical methods of treating the engorgement of the glans penis, at a deliberate or objective increase in the length of the penis in men, are accompanied by a high risk of depression in the postoperative period. Therefore, they can not be recommended as a routine. Lipectomy and surgical methods of treating the engorgement of the glans penis, at a deliberate or objective increase in the length of the penis in men, are accompanied by a high risk of depression in the postoperative period. Therefore, they can not be recommended as a routine.

Given that in most cases shortening the length of the penis in men is accompanied by psychological problems, it is extremely important for the surgeon with sufficient experience and knowledge to direct his attempts to maintain or increase penis length in men who underwent surgery. At present, there are a number of scientifically based, safe and effective ways to increase penis length and several developing adjuvant therapies that can provide the necessary length.

Clinical Management of Pregnancy in Women with Goodpasture Syndrome

Goodpasture’s syndrome, although a rare, but also a well-known autoimmune disease, affects mainly the kidneys and lungs of a person. This pathology is also found in pregnant women.

The article by Czech scientists published in January 2015 in the international peer-reviewed journal Gynecologic and Obstetric Investigations refer to cases of Good pesture syndrome occurring during pregnancy that can pose a serious threat to the life of the mother and fetus. The article summarizes the modern experience of the clinical diagnosis and treatment of Goodpasture’s syndrome during pregnancy.

Researchers, the authors of the article conducting an in-depth literature search, an overview of all published articles or case studies highlighting Goodpasture’s syndrome during pregnancy. The following data were extracted from each specific case of the syndrome during the woman’s pregnancy: the age of the patient, the gestational age, the good-for-pregnancy syndrome, the pregnancy of the child, the neonatal history of the child, and the patient’s kidney condition.

A review of the available literature showed 4 cases of Goodpasture’s syndrome during pregnancy. The mean age of the patients was 29.3 ± 2.5 years, and most of them were pervious, with an average ratio of 1.3 ± 1.5. The mean gestational age at the time of diagnosis was 12.5 ± 5.9 weeks. Therapy of Goodpasture’s syndrome. This fact is not consistent with international recommendations regarding the treatment of that syndrome. In addition, neonatal outcomes in neonates were also very individual, among all observed cases.

It is worth noting that the appearance of a good-for-life syndrome during pregnancy, after all, is very rare. This is an unusual complication of pregnancy, which is associated with significant harm to both the mother and the fetus. Pregnancy management in the case of pregnancy requires intensive care, close observation, monitoring of patient and fetus conditions, counseling of a number of specialists and interdisciplinary cooperation of doctors. However, to date, there are no unified protocols for administering goodpasture’s syndrome.

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Mice with experimental autoimmune glomerulonephritis represent a model of human antiglomerular disease of the renal basement membrane, which depends on the responses of antibodies and cells -chain domain of type IV collagen (α3IV-NC1). The purpose of this study was to further characterize the T-cell immune response in this syndrome.

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Ten days after the first immunization, α3IV-HC1-specific CD4 + cell-producing TNF-α, IFN-γ or IL-17A were detected in the spleen of mice. With the advent of necrotic or sickle-shaped glomerulonephritis, about 0.15% of renal CD4 + cells were specific for the α3IV-NC1 antigen. Using the peptides covering the entire domain of the α3IV-NC1 antigen, three immunodominant T-cell epitopes were identified. Immunization with these peptides did not lead to the clinical signs of experimental autoimmune glomerulonephritis, nor did it lead to the development of necrotic or sickle-shaped glomerulonephritis. However, in mice immunized with one of the peptides (STVKAGDLEKIISRC), circulating antibodies against the murine antigen α3IV-NC1, which were first detected at week 8, were developed.

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